Our Research
Bacterial Efflux Systems.
We are developing tools and platforms to facilitate the study of bacterial drug efflux pumps. Using these tools, we are investigating the physicochemical substrate specificities and physiological functions of these ancient resistance elements. We are curious to establish why these proteins are highly conserved. We will use this information to inform drug discovery endeavours to identify efflux inhibitors and new antibiotics that evade efflux.
Relevant publications:
Bacterial Adhesion & Antivirulence Strategies.
We are studying the genetic and molecular basis of bacterial adhesion to the host. This information is being used to guide a cutting-edge drug discovery program aimed at identifying anti-adhesive inhibitors. Most of our research focuses on the human pathogen Stpahylococcus aureus; however, we’re studying other pathogenic bacteria too.
Relevant publications:
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