Publications

Featured
Autolysin-mediated peptidoglycan hydrolysis is required for the surface display of Staphylococcus aureus cell wall-anchored proteins

Authors: Leonard A, Goncheva M, Gilbert S, Shareefdeen H, Petrie L, Thompson L, Khursigara C, Heinrichs D & Cox G. (2023).

Proceedings of the National Academy of Sciences (PNAS)

Chinks in the Armor: Pathogenesis-Based Strategies to Combat Bacterial Infections

Authors: Leonard C, Stoica C & Cox G. (2022)

Pathogenesis of Bacterial Infections in Animals

Exploring functional interplay amongst Escherichia coli efflux pumps

Authors: Goetz J, Kuehfuss N, Botschner A, Zhu S, Thompson L & Cox G. (2022)

Microbiology

A genetic platform to investigate the functions of bacterial drug efflux pumps

Authors: Teelucksingh T, Thompson L, Zhu S, Kuehfuss N, Goetz J, Gilbert S, MacNair C, Geddes-McAlister J, Brown E & Cox G. (2022)

Nature Chemical Biology

Staphylococcus aureus adhesion to the host

Authors: Berry K, Verhoef M & Cox G. (2022).

Annals of the New York Academy of Sciences

Old Problems and New Solutions: Antibiotic Alternatives in Food Animal Production.

Authors: Stoica C & Cox G. (2021).
Canadian Journal of Microbiology. 99(999)

Development and validation of a high-throughput whole cell assay to investigate Staphylococcus aureus adhesion to host ligands

Authors: LE Petrie, AC Leonard, J Murphy & G Cox
Journal of Biological Chemistry

Resistance-guided discovery of elfamycin producers with antigonococcal activity.

Authors: V Yarlagadda, R Medina, TA Johnson, KP Koteva, G Cox, MN Thaker, GD Wright.
ACS Infectious Diseases

The Evolutionary Conservation of Escherichia coli Drug Efflux Pumps Supports Physiological Functions

Authors: T Teelucksingh, L Thompson & G Cox.
The Journal of Bacteriology

Antibiotic dereplication using the Antibiotic Resistance Platform

Authors: H Zubyk, G Cox & GD Wright
The Journal of Visualized Experiments

Bacterial anti-adhesives: inhibition of Staphylococcus aureus nasal colonization

Authors: A Leonard, L Petrie & G Cox
ACS Infectious Diseases

Plazomicin retains antibiotic activity against most aminoglycoside modifying enzymes

Authors: G Cox, L Ejim, PJ Stogios, K Koteva, E Bordeleau, E Evdokimova, AO Sieron, A Savchenko, AW. Serio, KM. Krause & GD Wright.
ACS Infectious Diseases

Substrate recognition by a colistin resistance enzyme from Moraxella catarrhalis

Authors: PJ Stogios, G Cox, HL Zubyk, E Evdokimova, Z Wawrzak, GD Wright & A Savchenko
ACS Chemical Biology

Rox, a rifamycin resistance enzyme with an unprecedented mechanism of action

Authors: K Koteva*, G Cox*, JK Kelso*, MD Surette, HL Zubyk, L Ejim, P Stogios, A Savchenko, D Sørensen & GD Wright.
Cell Chemical Biology

A common platform for antibiotic dereplication and adjuvant discovery

Authors: G Cox, AO Sieron, AM King, G DePascale, AC Pawlowski, K Koteva & GD Wright.
Cell Chemical Biology

The rifampin phosphotransferase is a new class of antibiotic resistance kinase

Authors: PJ Stogios*, G Cox*, P Spanogiannopoulos, MC Pillon, N Waglechner, T Skarina, K Koteva, A Guarné, A Savchenko & GD Wright.
Nature Communications

Structural and molecular basis for resistance to aminoglycoside antibiotics by the adenylyltransferase ANT(2”)-Ia

Authors: G Cox, PJ Stogios, A Savchenko & GD Wright.
mBio

Inhibition of the ANT(2’’)-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic a-hydroxytropolones

Authors: DR Hirsch*, G Cox*, MP D’Erasmo, T Shakya, C Meck, N Mohd, GD Wright & RP Murelli.
Bioorganic & Medicinal Chemistry Letters.

An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria

Authors: G Cox, K Koteva & GD Wright.
Journal of Antimicrobial Chemotherapy

Mutagenesis Mapping of the Protein-Protein Interaction Underlying FusB-Type Fusidic Acid Resistance

Authors: G Cox, TA Edwards & AJ O'Neill.
Antimicrobial Agents and Chemotherapy

Intrinsic antibiotic resistance: Mechanisms, origins, challenges and solutions

Authors: G Cox G & GD Wright.
International journal of medical microbiology

"tet(U)" is not a tetracycline resistance determinant

Authors: JA Caryl, G Cox, S Trimble & AJ O'Neill.
Antimicrobial Agents and Chemotherapy

Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid

Authors: G Cox, GS Thompson, HT Jenkins, F Peske, A Savelsbergh, MV Rodnina, W Wintermeyer, SW Homans, TA Edwards & AJ O'Neill.
Proceedings of the National Academy of Sciences of the United States of America